2026

  1. Aristea Pavlou, Athanasios Katsouras, Maria Markou, Alkmini Nega, Sofia Bellou, Panagiota Koralli, Andriana Schiza, Nikolaos Chalmpes, Vasilis G. Gregoriou, Antonia Dimitrakopoulou-Strauss, Theodore Fotsis, Apostolos Avgeropoulos, Michael G. Siskos, Carol Murphy, and Christos L. Chochos. Rational Design of New Biocompatible Near-Infrared Conjugated Polymer Nanoparticles for Biomedical Applications. Macromolecules 2026 59 (3), 1429-1442 DOI: 10.1021/acs.macromol.5c01788

2025

  • Apostolidi A, Stergiopoulos G, Bellou S, Markou M, Fotsis T, Murphy C, Bagli E. Advances in Modeling the Inner Blood-Retinal Barrier: From Static Tissue Cell Cultures to Microphysiological Systems. Pharmaceuticals (Basel). 2025 Sep 13;18(9):1374 doi: 10.3390/ph18091374. 
  • Kalogeropoulos D, Asteris P, Bagli E, Vartholomatos G, Pateronis KA, Kalogeropoulos C.: Tonic Pupils in a Young Female with Vogt Koyanagi Harada Disease. Klin Monbl Augenheilkd 2025 doi:10.1055/a-2600-2318
  • Andreas P Katsenos, Efstathia Kotoula, ....Sofia Bellou, ..., Konstantinos I Tsamis. Modeling oxidative stress on neuronal dendrites and dendritic spines. Neuroscience 2026 Jan 9:592:157-166. doi: 10.1016/j.neuroscience.2025.11.037

2024

  • Vrettos E, Kyrkou S, Zoi V, Giannakopoulou M, Chatziathanasiadou M, Kanaki Z, Agalou A, Bistas V-P, Kougioumtzi A, Karampelas T, Diamantis D, Murphy C, Beis D, Klinakis A, Tamvakopoulos C, Kyristis A, Lexiou G, Tzakos A: A fluorescent gemcitabine prodrug that follows a nucleoside transporter-independent internalization and bears enhanced therapeutic efficacy with respect to gemcitabine. Chemistry 2024 Jun 28:e202401327 doi:10.1002/chem.202401327
  • Davri AS, Katsenos AP, Tulyaganova GK, Tzavellas NP, Simos YV, Kanellos FS, Konitsiotis S, Dounousi E, Niaka K, Bellou S, Lekkas P, Bekiari C, Batistatou A, Peschos D, Tsamis, K I: The SGLT2 inhibitor empagliflozin exerts neuroprotective effect against hydrogen peroxide-induced toxicity on primary neurons. Metab Brain Dis 2024, 40, 15 doi:10.1007/s11011-024-01478-6
  • Lazaridou A, Kalogeropoulos D, Bagli E, Christodoulou A, Kittas C, Kalogeropoulos C.: An Unusual Manifestation of Brucella-Associated Uveitis in a Young Male Patient. Klin Monbl Augenheilkd, 20224, doi:10.1055/a-2034-2180

 2023

  • Karydis-Messinis A, Moschovas D, Markou M, Gkantzou E, Vasileiadis V, Tsirka K, Gioti C, Vasilopoulos KC, Bagli E, Murphy C, Salmas CE, Giannakas AE, Hatziloukas E, Stamatis H, Paipetis A, Karakassides MA, Avgeropoulos A, Zafeiropoulos NE: Development, physicochemical characterization and in vitro evaluation of chitosan-fish gelatin-glycerol hydrogel membranes for wound treatment applications. Carbohydrate Polymer Technologies and Applications 6 (2023) 100338. https://doi.org/10.1016/j.carpta.2023.100338
  • Karydis-Messinis A, Moschovas D, Markou M, Tsirka K, Gioti C, Bagli E, Murphy C, Giannakas AE, Paitetis A, Karakassides MA, Avgeropoulos A, Salmas CE, Zafeiropoulos NE: Hydrogel Membranes from Chitosan-Fish Gelatin-Glycerol for Biomedical Applications: Chondroitin Sulfate Incorporation Effect in Membrane Properties. Gels 2023, 9, 844. doi: 10.3390/gels9110844

 2022

  • Chalmantzi V, Simitzi C, Papadopoulos A, Bagli E, Murphy C, Stratakis E, Fotsis T. Culturing Human Pluripotent Stem Cells on Micropatterned Silicon Surfaces. Methods Mol Biol 2022;2454:49-59. doi: 10.1007/7651_2021_428

 2021

  • Chalkiadaki K, Statoulla E, Markou M, Bellou S, Bagli E, Fotsis T, Murphy C, Ghogkas CG. Translational control in neurovascular brain development. R Soc Open Sci 2021; 8: 211088. doi: 10.1098/rsos.211088
  • Kostopoulou N*, Bellou S*, Bagli E, Markou M., Kostaras E, Hyvönen M, Kalaitzidis Y, Papadopoulos A, Chalmantzi V, Kyrkou A, Fotsis T and Murphy C. Embryonic Stem Cells Are Devoid of Macropinocytosis, a Trafficking Pathway for Activin A in Differentiated Cells. J Cell Sci 2021; 134: jcs246892. DOI: 10.1242/jcs.246892
  • Papadopoulos A, Chalmantzi V, Mikhaylichenko O, Hyvönen M, Stellas D, Kanhere A, Heath J, Cunningham DL, Fotsis T, Murphy C: Supporting data on combined transcriptomics and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells. Data in Brief 35 (2021) 106844. DOI: 10.1016/j.dib.2021.106844

  • Xydias D, Ziakas G, Psilodimitrakopoulos S, Lemonis A, Bagli E, Fotsis T, Gravanis A, Tzeranis SD, and Stratakis E. Three-dimensional characterization of collagen remodeling in cell-seeded collagen scaffolds via polarization second harmonic generation. Biomedical Optic Express 2021; 12: 1136-1156. eCollection 2021. DOI: 10.1364/BOE.411501

  • Kougioumtzi A, Chatziathanasiadou M, Vrettos EI, Sayyad N, Sakka M, Stathopoulos P, Mantzaris MD, Ganai M, Karpoormath R, Vartholomatos G, Tsikaris V, Lazarides T, Murphy C, Tzakos AG:  Development of novel GnRH and Tat 48-60 based luminescent agents with enhanced cellular uptake and bioimaging properties. Dalton Transactions, issue 26, 2021. DOI: 10.1039/d1dt00060h

  • Markou M, Kouroupis D, Fotsis T, Bagli E,  Murphy C: Vascularisation in 3D cell culture. Basic Concepts on 3D Cell culture. Springer. ISBN 978-3-030-66749-8. 2021.
  • Vrettos E, Karampelas T, Sayyad N, Kougioumtzi A, Syed N, Crook T, Murphy C, Tamvakopoulos C, Tzakos A: Development of programmable gemcitabine-GnRH pro-drugs bearing linker controllable “click” oxime bond tethers and preclinical evaluation against prostate cancer. Eur. J. Medicinal Chem. 211(2021)113018.

 2020

  • Papadopoulos A *, Chalmantzi V *, Mikhaylichenko O, Hyvönen M, Stellas D, Kanhere A, Heath J, Cunningham DL, Fotsis T and Murphy C: Combined transcriptomic and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells. Stem Cell Res 2020; 50: 102133.*These authors contributed equally
  • Markou M, Kouroupis D, Badounas F, Katsouras A, Kyrkou A, Fotsis T, Murphy C, Bagli E. Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell Phenotypes. Front Bioeng Biotechnol. 2020;8:278. eCollection 2020.
  • Christodoulou A, Bagli E, Gazouli M, Moschos MM, Kitsos G.: Association of MMP2-1306C/T Polymorphism with Ischemic Retinal Vein Occlusion. Arch Med Res, 2020, 51, 710-713.
  • James SL, …….E. Bagli…….., Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017. Inj Prev, 2020, 26, i96-i114.
  • Chatziralli I, Dimitriou E, Theodossiadis G, Bourouki E, Bagli E, Kitsos G, Theodossiadis P: Intravitreal ranibizumab versus vitrectomy for recurrent vitreous haemorrhage after pars plana vitrectomy for proliferative diabetic retinopathy: a prospective study. Int Opthalmol, 40, 841-847.

 2019

  • Global Burden of Disease Cancer, Collaboration……E. Bagli……:Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study, JAMA Oncol, 2019, 5, 1749-1768.
  • Christodoulou A, Bagli E, Gazouli M, Moschos MM, Kitsos G: Genetic polymorphisms associated with the prevalence of retinal vein occlusion in a Greek population. Int Ophthalmol, 39, 2637-2648.
  • Moschos MM, Diamantopoulou A, Gouliopoulos N, Droutsas K, Bagli E, Chatzistefanou K, Kitsos G, Kroupis C: TCF4 and COL8A2 Gene Polymorphism Screening in a Greek Population of Late-onset Fuchs Endothelial Corneal Dystrophy. In Vivo, 2019, 33, 963-971.

 2018

  • Kolettis TM, Bagli E, Barka E, Kouroupis D, Kontonika M, Vilaeti, AD, Markou M, Roumpi M, Maltabe V, La Rocca V, Agathopoulos S, Fotsis T: Medium-term Electrophysiologic Effects of aCellularized Scaffold Implanted in Rats After Myocardial Infarction . Cureus 2018; 10(7): e2959.
  • Chatziathanasiadou MV, Geromichalou EG, Sayyad N, Vrettos EI, Katsikoudi A, Stylos E, Bellou S, Geromichalos GD, Tzakos AG: Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. Amino Acids 2018, 50, 279-291.
  • Zikou AK, Kitsos G, Astrakas LG, Xydis VG, Spiliopoulos K, Bagli E, Argyropoulou MI: Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging. Eur J Radiol, 2018, 99, 82-87.

 2017

  • Vlaikou AM, Kouroupis D, Sgourou A, Markopoulos GS, Bagli E, Markou M, Papadopoulou Z, Fotsis T, Nakos G, Lekka ME, Syrrou M: Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs. Biochim Biophys Acta 2017, 1864(8): 1371-1381.
  • Lazaros L, Kitsou C, Kostoulas C, Bellou S, Hatzi E, Ladias P, Stefos T, Markoula S, Galani V, Vartholomatos G, Tzavaras T, Georgiou I: Retrotransposon expression and incorporation of cloned human and mouse retroelements in human spermatozoa. Fertil Steril, 207, 3,821-30.
  • Bagli E, Zikou AK, Agnantis N, Kitsos G: Mitochondrial Membrane Dynamics and Inherited Optic Neuropathies. In Vivo, 2017, 511-525.

 2016

  • Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S: VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis. J. Cell Sci. 2016, 129 (21): 4091-4104.
  •  Kouroupis D*, Kyrkou A*, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A, Georgoulis A, Murphy C, Fotsis T: Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Research. 2016, 17 (2): 448-457. *These authors contributed equally
  • Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C: Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Research. 2016, 17 (2): 458-460.
  • Mantzaris MD, Bellou S, Skiada V, Kitsati N, Fotsis T, Galaris D: Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis. Free Radic Biol Med. 2016, 97: 454-465.
  • Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A: Proteome changes during transition from human embryonic to vascular progenitor cells. J. Proteome Res 2016, 15 (6): 1995-2007.
  • Zannikou M, Bellou S, Eliades P, Hatzioannou A, Mantzaris MD, Carayanniotis G, Avrameas S, Lymberi P: DNA-histone complexes as ligands amplify cell penetration and nuclear targeting of anti-DNA antibodies via energy-independent mechanisms. Immunology, 2016, 147, 73-81.
  • Kitsou C, Lazaros L, Bellou S, Vartholomatos G, Sakaloglou P, Hatzi E, Markoula S, Zikopoulos K, Tzavaras T, Georgiou I: Exogenous retroelement integration in sperm and embryos affects preimplantation development. Reproduction, 2016, 152, 185-93.
  • Bagli E, Goussia A, Moschos MM, Agnantis N, Kitsos G: Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems. In Vivo, 2016, 30, 535-47.

 2015

  • Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM: The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst. 2015, 107(6):djv080.
  • Sanchez-Duffhues G, Fotsis T, ten Dijke P: Signal Transduction: Gain of Activin Turns Muscle into Bone. Curr Biol. 2015, 25(23): R1136-8.

 2014

  • Karali E., Bellou S., Stellas D., klinakis A., Murphy C, Fotsis T: VEGF signalling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis. Molecular & Cellular Oncology 1:3, e964024; 2014.
  • Karali E., Bellou S., Stellas D., klinakis A., Murphy C, Fotsis T: VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress. Molecular Cell 2014, 54: 559-72.
  • Kostaras E., Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signaling and trafficking. Methods in Enzymology 2014, 535:225-47.

 2013

  • Bellou S, Pentheroudakis G, Murphy C, Fotsis T: Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Letters 2013, 338: 219-28.
  • Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T*, Murphy C*: SARA and RNF11 Interact with Each Other and ESCRT-0 Core Proteins and Regulate Degradative EGFR Trafficking. Oncogene 2013, 32 (44): 5220-32. *These authors contributed equally to this work.
  • Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4 (2).
  • Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene. 2013, 32 (14): 1831- 42.
  • Tsatsoulis A, Mantzaris MD, Bellou S, Andrikoula M: Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective. Metabolism 2013, 5,622-33.

 2012

  • Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012 May 14;11(1):35.
  • Stoyianni A, Goussia A, Pentheroudakis G, Siozopoulou V, Ioachim E, Krikelis D, Golfinopoulos V, Cervantes A, Bobos M, Fotsis T, Bellou S, Fountzilas G, Malamou-Mitsi V, Pavlidis N: Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res. 2012, 32(4):1273-81.

 2011

  • Sflomos G, Kostaras, E, Panopoulou E, Pappas N, Kyrkou K, Politou A, Fotsis T, Murphy C: ERBIN is a novel SARA- interacting Protein: Competition between SARA and SMAD2/3 for binding to ERBIN, J Cell Sci. 2011, 124: 3209-22.
  • Markoula S, Giannopoulos S, Asproudis I, Kostoulas C, Nikas A, Bagli E, Kyritsis AP, Georgiou I: Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy. Mol Vis, 2011, 17, 1254-60.

 2010

  • Moumtzi SS, Roberts LM, Joyce T, Euagelidou M, Probert L, Frillingos S, Fotsis T, Pintzas A: Gene expression profile associated with oncogenic RAS-induced senenscence, cell death and transforming properties in human cells. Cancer Invest 2010, 28: 563-587.

 2009

  • Bellou S, Mark A Hink, AM, Bagli E, Panopoulou E, Bastiaens PIH, Murphy C, Fotsis T: VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells. Am J Physiol Cell Physiol 2009 297: C1477-89.
  • Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C: Control of TGFβ signal transduction by small GTPases. FEBS J 2009, 276: 22947-65.
  • Goulas V, Exarchou V, Troganis AN, Psomiadou E, Fotsis T, Briasoulis E, Gerothanassis IP: Phytochemicals in olive- leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009, 53: 600-608.
  • Kitsos G, Gartzios C, Asproudis I, Bagli E: Central corneal thickness in subjects with glaucoma and in normal individuals (with or without pseudoexfoliation syndrome). Clin Ophthalmol, 2009, 3, 537-42.
  • Bagli E, Gartzios C, Asproudis I, Kitsos G: Comparison of one-site versus two-site phacotrabeculectomy without the use of antimetabolites intraoperatively in patients with pseudoexfoliation glaucoma and primary open-angle glaucoma. Clin Ophthalmol, 2009, 3, 297-305.
  • Kitsos G, Zikou AK, Bagli E, Kosta P, Argyropoulou MI: Conventional MRI and magnetisation transfer imaging of the brain and optic pathway in primary open-angle glaucoma. Br J Radiol, 2009, 82, 896-900.

 2007

  • Murphy C: Endo-fin-ally a SARA for BMP receptors. J Cell Sci 2007, 120:1153-1155.

 2006

  • Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H: Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines. Fitoterapia 2006, 77:358-366.

 2005

  • Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. J Biol Chem 2005, 280:26406-26414.
  •  Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N. Matrix metalloproteinases in carcinoma of unknown primary. Cancer. 2005, 104(10): 2282-7.
  • Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N: Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1. BMC Cancer 2005, 5(1): 25.
  • Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T: Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res. 2005, 65(5): 1877-86.

 2004

  • Adlercreutz H, Kiuru P, Rasku S, Wahala K, Fotsis T: An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine. J Steroid Biochem Mol Biol. 2004, 92(5): 399-411.
  • Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res. 2004, 64(21): 7936-46.
  • Roussou I, Lambropoulos I, Pagoulatos GN, Fotsis T, Roussis IG: Decrease of heat shock protein levels and cell populations by wine phenolic extracts. J Agric Food Chem. 2004, 52(4): 1017-24.

 2002

  • Hatzi E, Murphy C, Zoephel A, Ahorn A, Tontsch U, Bamberger A-M, Yamauchi-Takihara Y, Schweigerer L, Fotsis T: N-myc Oncogene Overexpression Down-Regulates Leukemia Inhibitory Factor in Neuroblastoma. Eur. J. Biochem. 2002, 269: 3732-3741.
  •  Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn A, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara Y, Ziche M, Rofstad EK, Schweigerer L, Fotsis T: N-myc Oncogene Overexpression Down-Regulates IL-6; Evidence that IL-6 Inhibits Angiogenesis and Suppresses Neuroblastoma Tumour Growth. Oncogene 2002, 16: 3552-3561.
  • Panopoulou, E., Gillooly, D.J., Jeffrey, J.L., Zerial, M., Stenmark, H., Murphy, C*., and Fotsis, T*. Early Endosomal Regulation of Smad-Dependent Signaling in Endothelial Cells. J. Biol. Chem. 2002, 277: 18046-18052.  *These authors contributed equally to this work
  • Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., and Roussos, C.. Luteolin reduces LPS-induced lethal toxicity and expression of pro-inflamatory molecules in mice. Am. J. Resp. Crit. Care Med. 2002, 165: 818-823.
  • Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T: Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. EMBO Rep 2002, 3:361-366.

 2001

  • Murphy, C., Saffrich, R., Olivo-Marin, J-C., Giner, A., Ansorge, W., Fotsis, T., and Zerial, M. Dual function of rhoD in vesicular movement and cell motility. Eur. J. Cell Biol. 2001, 80: 391-398.
  • Xagorari, A., Papapetropoulos, A., Mavromatis, A., Economou, M., Fotsis, T., and Roussos, C. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J. Pharmacol. Exp. Therap. 2001, 296: 181-187.

 2000

  • Breit, S., Ashman, K., Wilting, J., Rössler, J., Hatzi, E., Fotsis, T*., and Schweigerer, L*. The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A. Cancer Res. 2000, 60: 4596-4601. *These authors contributed equally to this work
  • Breit, S., Rössler, J., Fotsis, T., and Schweigerer, L. N-myc down-degulates activin A. Biochem. Biophys. Res. Commun. 2000, 274: 405-409.
  • Hatzi E, Breit S, Zoephel A, Ashman K, Tontsch U, Ahorn H, Murphy C, Schweigerer L, Fotsis T: MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterization. Adv Exp Med Biol 2000, 476:239-248.

 1999

  • Fotsis, T., Breit, S., Lutz, W., Rössler, J., Hatzi, E., Schwab, M., and Schweigerer, L. Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells. Eur. J. Biochem. 1999, 263: 757-764.
  • Gong, H., Zolter, F., von Recklinghausen, G., Rossler, J., Breit, S., Havers, W., Fotsis, T., Schweigerer, L. Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis. Biochem. Biophys. Res. Commun. 1999, 261: 10-14.
  • Pappa, A., Seferiadis, K., Fotsis, T., Shevchenko, A., Marselos, M., Tsolas, O., Messinis, I.E. Purification of a candidate gonodotrophin surge attenuating factor from human follicular fluid. Hum. Reprod. 1999, 14: 1449-1456.
  • Pappas P, Stephanou P, Sotiropoulou M, Murphy C, Salminen L, Marselos M: Effects of tamoxifen and toremifene on ALDH1 and ALDH3 in human retinal pigment epithelial cells and rat liver. Adv Exp Med Biol 1999, 463:151-158.
  • McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M: Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell 1999, 98:377-386

 1998

  • Adlercreutz, H., and Fotsis, T. Comment on altered hydroxylation of estrogen in patients with postmenopausal osteopenia. J. Clin. Endocrinol. Metab. 1998, 83: 4170-4171.
  • Zacchi P, Stenmark H, Parton RG, Orioli D, Lim F, Giner A, Mellman I, Zerial M, Murphy C: Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. J Cell Biol 1998, 140:1039-1053.
  • Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H: EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 1998, 394:494-498.

 1997

  • Kruse, F.T., Joussen, A.M., Fotsis, T., Schweigerer, L., Rohrschneider, K., Volcker, H.E. Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonopids. Ophthalmologe 1997, 94: 152-156.
  • Fotsis, T., Pepper, M.S., Aktas, E., Breit, S., Rasku, S., Adlercreutz, H., Wähälä, K., Montesano, R., and Schweigerer,L. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Research 1997, 57: 2916-2921.
  • Murphy C, Zacchi P, Parton RG, Zerial M, Lim F: HSV infection of polarized epithelial cells on filter supports: implications for transport assays and protein localization. Eur J Cell Biol 1997, 72:278-281.

 1996

  • Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T., and Mann, M. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 1996, 379: 466-469.
  • Mazur, W., Fotsis, T., Wähälä, K, Ohjala, S., Salakka, A., and Adlercreutz, H. Isotope dilute gas chromatographic- mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Analytical Biochemistry 1996, 233: 169-180.
  • Zuniga Mejia Borja A, Murphy C, Zeller R: AltFGF-2, a novel ER-associated FGF-2 protein isoform: its embryonic distribution and functional analysis during neural tube development. Dev Biol 1996, 180:680-692
  • Murphy C, Saffrich R, Grummt M, Gournier H, Rybin V, Rubino M, Auvinen P, Lutcke A, Parton RG, Zerial M: Endosome dynamics regulated by a Rho protein. Nature 1996, 384:427-432.
  • Kretschmer C*, Murphy C*, Biesinger B, Beckers J, Fickenscher H, Kirchner T, Fleckenstein B, Ruther U: A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice. Oncogene 1996, 12:1609-1616.* joint first authors.

 1995

  • Pipili-Synetos, E., Papageorgiou, A., Sakkoula, E., Sotiropoulou, G., Fotsis, T., Karakiulakis, G., and Maragoudakis,M.E. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br. J. Pharmacol. 1995, 116: 1829-1834.
  • Musey, P.I., Adlercreutz, A., Gould, K.G., Collins, D.C., Fotsis, T., Bannwart, C., Mäkelä, T., Wähälä, K., Brunow, G., and Hase, T. Effect of diet on lignans and isoflavonoids phytoestrogens in chimpanzees. Life Sciences 1995, 57: 655-664.
  • Lonning, P.E., Helle, S-I., Johannessen, D.C., Adlerctreutz, H., Lien, E.A., Tally, M., Ekse, D., Fotsis, T., Anker, G.B., and Hall, K. Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-1 and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patients. Clinical Endocrinology 1995, 42: 23-30.
  • Lonning, P.E., Johannessen, D.C., Lien, E.A., Ekse, D., Fotsis, T., and Adlercreutz, H. Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal brease cancer patients. J. Steroid Biochem. Mol. Biol. 1995, 52: 491-496.
  • Fotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R., and Schweigerer, L. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J. Nutr. 1995, 125: 790S-797S.
  • Adlercreutz, H.T., Goldin, B.R., Gorbach, S.L., Höckerstedt, K.A.V., Watanabe, S., Hämäläinen, E.K., Markkanen, M.H., Mäkelä, T.H., Wähälä, K.T., Hase, T.A. and Fotsis, T. Soybean phytoestrogen intake and cancer risk. J. Nutr. 1995, 125: 757S-770S.
  • Adlercreutz, H., Fotsis, T., Kurzer,M., Wähälä, K., Mäkelä,T., and Hase, T. Isotope dilution gas chromatographic- mass spectrometric method for the determination of unconjugated lignans and isoflavonoids in human feces, with preliminary results in omnivorous and vegetarian women. Analytical Biochemistry 1995, 225: 101-108.
  • Adlercreutz,H., van der Wildt, J., Kinzel, J., Attala, H., Wähälä, K., Mäkelä,T., Hase, T., and Fotsis, T. Lignan and isoflavonoid conjugates in human urine. J. Steroid Biochem. Mol. Biol. 1995, 52: 97-103.
  • Murphy C, Zerial M: Expression of Rab proteins during mouse embryonic development. Methods Enzymol 1995, 257:324-332.
  • Murphy C, Beckers J, Ruther U: Regulation of the human C-reactive protein gene in transgenic mice. J Biol Chem 1995, 270:704-708.

 1994

  • Adlercreutz, H., Fotsis, T., Watanabe, S., Lampe, J.,Wähälä, K., Mäkelä,T., and Hase, T. Determination of lignans and isoflavonoids in plasma by isotope dilution gas chromatograohy-mass spectrometry. Cancer Detection and Prevention 1994, 18: 259-271.
  • Adlercreutz,H., Gorbach,S.L., Goldin, B.R., Woods, M.N., Dwyer, J.T., Höckerstedt, K.A.V., Wähälä, K.T., Hase, T., Hämäläinen, E.K., and Fotsis, T. Diet and urinary profile in various populations. A preliminary report. Polycyclic Aromatic Compounds, 1994, 6: 261-273.
  • Fotsis, T., Zhang, Y., Pepper, M.S., Adlercreutz, H., Montesano, R., Nawroth, P.P., and Schweigerer, L. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumour growth. Nature 1994, 368: 237-239.
  • Murphy C, Kretschmer C, Biesinger B, Beckers J, Jung J, Desrosiers RC, Muller-Hermelink HK, Fleckenstein BW, Ruther U: Epithelial tumours induced by a herpesvirus oncogene in transgenic mice. Oncogene 1994, 9:221-226.
  • Lutcke A, Parton RG, Murphy C, Olkkonen VM, Dupree P, Valencia A, Simons K, Zerial M: Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. J Cell Sci 1994, 107 (Pt 12):3437-3448.

 1993

  • Johannessen, G. C, Adlerceutz, H., Fotsis, T., and Lonning, E. Plasma and urinary oestrogens in breast cancer patients on treatmnet with 4-hydroxyandrostenedione. Brit. J. Cancer 1993, 68: 393-398.
  • Adlercreutz, H., Fotsis, T., Lampe, J., Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand. J. Clin. Lab. Invest. 1993, 53 (Suppl 215): 5-18.
  • Fotsis, T., Pepper, M., Adlercreutz, H., Fleischmann, G., Hase, T., Montesano, R. and Schweigerer, L. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl. Acad. Sci. 1993, 90: 2690-2694.

 1992

  • Schweigerer, L., Christeleit, K., Fleischmann, G., Adlercreutz, H., Wähälä, K., Hase, T., Schwab, M., Ludwig, R., and Fotsis, T. Identification in human urine of a natural growth inhibitor for cells derived from solid pediatric tumours. Eur. J. Clin. Invest. 1992, 22: 260-264.
  • Schweigerer, L., and Fotsis, T. Angiogenesis and angiogenesis inhibitors in pediatric diseases. Eur. J. Pediatr. 1992, 151: 472-476.

 1991

  • Schweigerer. L., and Fotsis, T. Erhöhte Expression des MYCN Ongogens in humanen Neuroblastomzellen und mögliche, neue Therapie-Ansätze. Klin. Pädiatr. 1991, 203: 319-322.
  • Adlercreutz, H., Honjo, H., Higashi, A., Fotsis, T., Hämäläinen, E., Hasegawa, T., and Okada, H. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 1991, 54: 1093-1100.
  • Adlercreutz, H., Fotsis, T., Bannwart, C., Wähälä, K., Brunow, G., and Hase, T. Isotope dilution gas chromatographic- mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clin. Chem. Acta. 1991, 199: 263-278.
  • Hämäläinen, E.,Fotsis, T., and Adlercreutz, H. A gas chromatographic method for the determination of neutral profiles in urine, including studies on the effect of oxytetracycline administration on these men. Clin. Chim. Acta 1991, 199: 205-220.

 1990

  • Schweigerer, L., Scheurich, P., and Fotsis, T. Enhanced MYCN oncogene expression in human neuroblastoma cells results in increased susceptibility to growth inhibition by TNFa. Biochem. Biophys. Res. Commun. 1990, 170: 1301- 1307.
  • Fotsis, T., Murphy, C., and Gannon, F. Nucleotide sequence of the bovine insulin-like growth factor I (IGF-I) and its IGF-IA precursor. Nucl. Acids Res. 1990, 18: 676.

 1989

  • Adlercreutz, H., Fotsis, T., Höckerstedt, K., Hämäläinen, E., Bannwart, C., Bloigu, S., Valtonen, A., and Ollus, A. Diet and urinary estrogen profile in premenopausal omnivorous and vegetarian women and in premenopausal women with breast cancer. J. Steroid Biochem. 1989, 34: 527-530.

 1987

  • Murphy, C., Fotsis, T., Pantzar, P., Adlercreutz, H., and Martin, F. Analysis of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen levels in cytosol and KCl-nuclear extracts of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 28: 609-618.
  • Murphy, C., Fotsis, T., Adlercreutz, H., and Martin, F. Analysis of tamoxifen and 4-hydroxytamoxifen levels in immature rat uterine cytoplasm and KCL-nucler extracts by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 28: 289-299.
  • Fotsis, T. The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS -II. Fractionation and quantitation of the main groups of estrogen conjugates. J. Steroid Biochem. 1987, 28: 215-226.
  • Fotsis, T., and Adlercreutz, H. The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS -I. Quantitation of estrogens after initial hydrolysis of conjugates. J. Steroid Biochem. 1987, 28: 203- 213.
  • Fotsis, T., Shah, H.P., Härkönen, M., and Adlercreutz, H. Fluoroenzymatic cycling assay (FECA) for the determination of catechol estrogen monomethyl ethers in human urine. Neurochemical Research 1987, 12: 507-513.
  • Adlercreutz, H., Höckerstedt, K., Bannwart, C., Bloigu, S.,Hämäläinen, E., Fotsis, T., and Ollus, A. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem. 1987, 27: 1135-1144.
  • Murphy, C., Fotsis, T., Pantzar, P., Adlercreutz, H., and Martin, F. Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 26: 547-555.

 1986

  • Adlercreutz, H., Fotsis, T., Bannwart, C., Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens,in urine of women on various habitual diets. J. Steroid Biochem. 1986, 25: 791-797.
  • Korpela, J.T., Fotsis, T., and Adlercreutz, H. Multicomponent analysis of bile acids in faeces by anion exchange and capillary column gas-liquid chromatography; application in oxytetracycline treated subjects. J. Steroid Biochem. 1986, 25: 277-284.
  • Adlercreutz, H., Musey, P.I., Fotsis, T., Bannwart, C.,Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Identification of lignans and phytoestrogens in urine of chimpanzees. Clin. Chim. Acta 1986, 158: 147-154.
  • Adlercreutz, H., Fotsis, T, Bannwart, C., Hämäläinen, E.K.,Bloigu, S., and Ollus, A. Urinary estrogen profile determination in young Finnish vegetarian and omnivorous women. J. Steroid Biochem. 1986, 24: 289-296.

 1984

  • Bannwart, C., Adlercreutz, H., Fotsis, T., Wähälä, K., Hase, T., and Brunow, G. Identification of O- desmethylangolesin, a metabolite of daidzein, and of metairesinol, one likely plant precursor of the animal lignan enterolactone, in human urine. Finn. Chem. Lett. 1984, 45: 120-125.
  • Hämäläinen, E.K., Fotsis, T., and Adlercreutz, H. Rapid and reliable separation of 5a-dihydrotestosterone from testosterone on silica gel microcolumns. Clin. Chim. Acta 1984, 139: 173-177.
  • Bannwart, C., Fotsis, T., Heikkinen, R., and Adlercreutz,H. Identification of the isoflavonic phytoestrogen daidzeinin human urine. Clin. Chim. Acta 1984, 136: 165-172.

 

 1983

  • Antila, E., Fotsis, T., Wartiovaara, J., and Adlercreutz, H. Steroid metabolism in human teratocarcinoma cell line PA1. J. Steroid Biochem. 1983, 19: 1583-1590.
  • Heikkinen, R., Fotsis, T., and Adlercreutz, H. Use of ion exchange chromatography in steroid analysis. J. Steroid Biochem. 1983, 19: 175-180.
  • Fotsis, T., and Heikkinen, R. Selective chromatographic fractionation of catechol estrogens on anion exchangers in borate form. J. Steroid Biochem. 1983, 18: 357-363.

 1982

  • Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J.T., Woods, M., Goldin, B.R., and Gorbach, S.L.. Excretion of the lignans, enterolactone and enterodiol, and of equol in omnivorous and vegetarian postmenopausal women and in breast cancer. Lancet 1982, 2: 1295-1299.
  • Fotsis, T., Heikkinen, R., Adlercreutz, H., Axelson, M., and Setchell, K.D.R. Capillary gas chromatographic method for the analysis of lignans in human urine. Clin. Chim. Acta 1982, 121: 361-371.
  • Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J.T., Goldin, B.R., Gorbach, S.L., Lawson, A.M., and Setchell, K.D.R. Diet and urinary excretion of lignans in female subjects. Medical Biology 1981, 59: 259-261.

 1981

  • Heikkinen, R., Fotsis, T., and Adlercreutz, H. Reversed phase C18 cartridge for extraction of estrogens from urine and plasma. Clin. Chem. 1981, 27: 1186-1189.
  • Fotsis T, Adlercreutz H, Järvenpää P, Setchell KDR, Axelson M, Sjövall J: Group separation of steroid conjugates by DEAE-Sephadex anion exchange chromatography. J. Steroid Biochem. 1981, 14: 457-463.

 1980

  • Fotsis T, Järvenpää P, Adlercreutz H: Identification of 4-hydroxyestriol in pregnancy urine. J. Clin. Endocrinol. Metab. 1980, 51: 148-151.
  • Järvenpää P, Kosunen T, Fotsis T, Adlercreutz H: In vitro metabolism of estrogens by isolated intestinal micro-organisms and by human fecal microflora. J. Steroid Biochem. 1980, 13: 345-349.
  • Fotsis T, Järvenpää P, Adlercreutz H: Purification of urine for quantification of the complete estrogen profile. J. Steroid Biochem. 1980, 12: 503-508.

 1979

  • Järvenpää P, Fotsis T, Adlercreutz H: Ion exchange purification of estrogens. J. Steroid Biochem. 1979, 11: 1583-1588.
  • Adlercreutz H, Martin F, Järvenpää P, Fotsis T: Steroid adsorption and enterohepatic recycling. Contraception 1979, 20: 201-223.