Title: BRAINPRECISION_National Research Network for the Investigation of the Genetic Basis of Alzheimer’s and Parkinson’s Neurodegenerative Diseases, the Identification of Reliable Biomarkers, and the Development of Innovative Computational Technologies and Therapeutic Strategies Based on Precision Medicine.

Funding Source: "Greece 2.0" National Recovery and Resilience Plan, funded by the European Union – NextGenerationEU.

Contract Number: TAEDR-0535850

Budget: 100,000 €

Duration: 05/2023-12/2025

Title: Molecular Mechanisms of Vessel Morphogenesis - MorphoVess (https://morphovess.project.uoi.gr/index.html)

Funding Source: Hellenic Foundation for Research and Innovation

Contract Number: 15009

Role: Co-ordinator: Carol Murphy. Collaborating PI Periklis Papadopoulos. T. Fotsis: key collaborator.

Budget: 400.000 €

Duration: 2024-2025

Title: Human retinal organoids as a model system to study retinal diseases

Funding Source: ELIDEK PhD student fellowship

Contract Number: 06498

Researchers: Awarded to Aikaterini Apostolidi

Role: Supervisor Carol Murphy, co-supervisor Eleni Bagli and T Fotsis.

Budget: 32.400 €

Duration: 2022-2025

Title: Development of novel therapeutic strategies against Parkinsons disease.

Funding Source: ESPA 2014-2020 co-financing of Greece/European Union.

Contract Number: MIS 5095050

Budget : Total budget:1,000,000 €. Budget for the Ioannina team: 200,000 €.

Coordinator: Prof. G. Garinis, IMBB-FORTH, Crete. Co-PIs in Ioannina C. Murphy and C. Gkogkas.

Duration: 2020-2022.

Title: Modelling neurological disorders using graphene-based neurovascular organoids
derived from pluripotent human cells

Funding Source: competitive FORTH Inter-Institutional Interdisciplinary award.

Budget: 60,000€.

Co-ordinator: C. Gkogkas,IMBB-BR, FORTH, Ioannina. Co-PIs: C. Murphy, IMBB-BR, FORTH, Ioannina and G. Deligeorgis, IESL, FORTH, Heraklion, Crete.

Duration: 2020-2022.

Title: Creation of distinct types of Mural Cells by the differentiation of human pluripotent stem cells and their application in vascularised tissue constructs.

Funding Source: ESPA 2014-2020 co-financing of Greece/European Union.

Contract Number: MIS: 5047550

Budget: 45,500 €.

Principal Investigator for IMBB-BR: Carol Murphy

Duration: 2019-2021.

Title: Molecular Mechanisms of VEGF in Vasculogenesis and Applications in Regenerative Medicine.

Funding Source ΙΚΥ (State Scholarship Foundation); Type of Grant: PA 2014-2020/Human Resources Development, Education and Lifelong Learning: Strengthening human research potential through doctoral research.

Thesis Supervisor: Theodore FOTSIS; Ph.D Student: Maria MARKOU; Host Organisation: University of Ioannina; C. Murphy role: key collaborator.

Contract Number: MIS 5000433.

Budget :29.408 €.

Duration: 09.12.2019 – 08.12.2019.

Title: Integrated Envirinomental Management (2.1); Title: Promoting Silver tourism throughvalorization of MED
diet and wellbeing routes in the CBC area; Acronym: Silver wellbeing

Funding Source: Hellenic Ministry of Finance and Development & Tourism; Type of Grant: PA 2014-2020/Interreg Greece-Italy/2.

Contract Number: 5003627

Budget (for the team): Budget: 891.999,12 €. Budget for IMBB-BR: 158.619,25 €.

Principal Investigator for IMBB-BR: Theodore Fotsis; C. Murphy role: Key collaborator.

Duration: 2018-2021.

Title: Molecular mechanisms of asymmetric cell division during stem cell differentiation.

Funding Source ΙΚΥ (State Scholarship Foundation); Type of Grant: PA 2014-2020/Human Resources Development, Education and Lifelong Learning: Strengthening human research potential through doctoral research.

Thesis Supervisor: Theodore Fotsis; Ph.D Student: Evangelos DROUGKAS; Host Organisation: University of Ioannina; C. Murphy role: key collaborator.

Contract Number: SPA00225-10.

Budget (for the team): 23.391 €.

Duration: 2018 –2020.

Title: Advanced Research Activities in Biomedical Technology and Agri-food; Acronym: ΒΙΤΑΔ. FORTH;

Funding Source: Hellenic Ministry of Finance and Development; PA 2014-2020/Competitiveness, Entepreneurship & Innovation

Contract Number: MIS 5002469;

Budget: 2.319.500 €. Budget for IMBB-BR: 600.000 €.

Responsible in Ioannina : Theodore Fotsis.

Duration: 2017-2020.

Title: Targeted Medications: Endocytosis, trafficking and Molecular Mechanism of Action.

Funding Source ΙΚΥ (State Scholarship Foundation); Type of Grant: PA 2014-2020/Human Resources Development, Education and Lifelong Learning: Strengthening human research potential through doctoral research.

Thesis Supervisor: Theodore FOTSIS; Ph.D Student: Anastasia KOUGIOUMTZI; Host Organisation: University of Ioannina; C. Murphy role: key
collaborator.
Contract Number: MIS 5003404.
Budget (for the team): 29.408 €.
Duration: 2017 –2018.

Title: Bioimaging network, IncuCyte

Budget: Total budget 4,000,000 €, 204,500 € for IMBB-BR.

Participants T. Fotsis and C. Murphy

Duration:2017

Title: Elucidating Activin A receptor complex trafficking and signalling: link to cell differentiation.

Funding Source: The Centre of Membrane Proteins and Receptors (COMPARE). http://www.birminghamnottingham.ac.uk/compare/

Contract Number: DLABGBI1270

Budget (for the team): £25,000.

PI responsible C Murphy.

Duration: 2016-2017

Title: Kripis I: Biology, Biophotonics, and Health: Modern technological approachesand applications in the filed of Biology, Photonics and Health.

Funding Source: GSRT. Research program for the development of research institutes.

Contract Number: MIS 448301

Budget (for the team): Budget for IMBB-BR: 300,000 €; Budget for Murphy 6,000€

Duration: 2015-2017.

Title: Kripis I: Biology, Biophotonics, and Health: Modern technological approachesand applications in the filed of Biology, Photonics and Health.

Funding Source: GSRT. Research program for the development of research institutes.

Contract Number: MIS 448301

Budget (for the team): Budget for IMBB-BR: 300,000 €; Budget for Theodore Fotsis 29,737 €

Duration: 2015-2017.

Title: POM “PIK3CA Oncogenic Mutations in Breast and Colon Cancers: Development of Targeted Anticancer Drugs and Diagnostics.

Funding Source: National Strategic Reference Framework (NSRF, GSRT)

Contract Number: 09SYN-11-675

Budget (for the team): Total budget: 1.962.900 €, for IMBB-BR 189,000 €.

Coordinator: A. Efstratiadis, GD-BRFAA. Responsible for the Ioannina team: Theodore Fotsis

Duration: 2013-2015

Title: Role and Mechanisms of Asymmetric Cell Division in Stem Cell Differentiation. AdiSC.

Funding Source: National Strategic Reference Framework (NSRF, GSRT)

Budget: Total budget: 600.000 €. BRI-FORTH: 200,000 €.

Coordinator: Theodore Fotsis.

Duration: 2012-2015.

Title: Remodeling Diabetic and Ischemic Retinal Vasculature Using Progenitor Stem Cells, ReVaReSC

Funding Source:GSRT

Contract Number: LS7 (2012)

Researchers: Eleni Bagli, Carol Murphy, Theodore Fotsis

Role: Scientific responsible Carol Murphy

Budget: € 150.000

Duration: 2011 – 2015

Title: StemCycle. Stem Cycle Variations: Comparing the Stem Cell and Cancer Cell Life Cycles.

Funding source: NSRF

Budget: Budget: 600.000 €. BRI-FORTH 88,500 €.

Coodinator: Zoi Lygerou. Responsible in Ioannina: C. Murphy.

Duration: 2011-2015

Title: Treating the Rupture of Anterior Cruciate Ligament: Regeneration using Stem Cells and Tissue Engineering.

Funding Source: National Strategic Reference Framework (NSRF) 2007-2013 – Region of Epirus.

Budget (for the team): 147.922,25 €.

Role: Scientific responsible Theodore Fotsis. Carol Murphy: key collaborator.

Duration: 2011 –2014

Title: NoisePlus. Mechanisms of Induced Pluripotency:From Transcriptional Noise to Stem Cell Therapies.

Funding Source: National Strategic Reference Framework.

Contract Number: 09SYN-21-969

Budget (for the team): Total budget: 1.680.000 €, for IMBB-BR 444,500 €.

Role: Coordinator: D. Thanos. Responsible in Ioannina: S. Georgatos. Work package leader C. Murphy: reprogramming human somatic cells to pluripotency.

Duration: 2007-2013

Title: Bone Regeneration Using Keratin-Based Biomaterials

Funding Source: National Strategic Reference Framework (NSRF), (GSRT).

Budget (for the team): 150,000 €

Duration: 2007-2013

Title: Confocal microscopy Unit

Funding source: Region of Epirus

Budget: 800,000 € for IMBB-BR, Coordinator T. Fotsis

Duration: 2010

Title: Tracking the Endocytic Routes of Polypeptide Growth Factor Receptor Complexes and their Modulatory Role on Signalling (EndoTrack).

Funding Source: FP6 EU integrated project.

Contract Number: EndoTrack LSH-2004-1.1.5-2

Budget (for the team): Total budget: 10,864,508 €. For IMBB-BR 883,000 €

Role: Coordinator: M. Zerial. Responsible in Ioannina: C. Murphy

Duration: 2006-2010

Title: Pulmotension. Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling.

Funding Source: FP6 EU integrated project.

Contract Number: LSHM-CT-2006-018725

Budget : Total budget: 11.400.00 €. BRI-FORTH 240.045 €.

Title: Investigation of the role of Rho GTPases in the regulation of the genomic and nongenomic responses
of cells to cytokines.

Funding Source: GRST

Contract Number: PENED 2003/03ED688

Budget(for the team): Total Budget 180,000 €, for IMBB-BR 44,625 €.

Coordinator: C.Stournaras, University of Crete, Responsible for the Ioannina group: C. Murphy.

Duration: 2006-2010

Title: The role of lipid rafts and caveolae in thrombosis and angiogenesis.

Funding source: Ministry of Education

Budget: 50.000 €. Principal investigator: T. Fotsis.

Duration: 2005-2008

Title: Applications of light microscopy in biomedical research and diagnosis.

Funding Source: GSRT

Budget: Total budget: 180,000 €. BRI-FORTH: 37,153 €.

Co-ordinator: Ch. Boleti, Pasteur Institute, Athens. Responsible for the Ioannina group: C. Murphy.

Duration: 2004-2005